3D bioprinting ndi nsanja yapamwamba kwambiri yopanga yomwe ingagwiritsidwe ntchito kusindikiza minyewa yama cell ndipo pamapeto pake ziwalo zofunika kwambiri.Izi zitha kutsegulira maiko atsopano azachipatala pomwe zikupindulitsa mwachindunji odwala omwe akufunika kusintha ziwalo.
M'malo modikirira wopereka woyenerera kapena kuika thupi pachiswe pokana chiwalo choikidwacho, odwala amakhala ndi chiwalo chokhazikika chokhazikitsidwa ndi cholinga choloŵa m'malo chomwe chili ndi vuto.Komabe, ngakhale kupita patsogolo kwa 3D bioprinting pazaka 20 zapitazi, sikunapitebe patsogolo kwambiri kuti apange mapangidwe amtundu wa 3D biomimetic.
Malinga ndi ofufuza a Singapore University of Technology and Design (SUTD), Nanyang Technological University (NTU) ndi Asia University, matekinoloje a chikhalidwe cha minofu makamaka akuyenera kufulumizitsidwa kuti athetse vuto la kukhwima kwa 3D bioprinted multicellular tissue.Pepala lawo lofufuza, lotchedwa “Ndisindikizireni chiwalo!Chifukwa chiyani sitinabwere?yasindikizidwa mu Advances in Polymer Science.
Mu pepala ili, ochita kafukufuku amaperekanso ndondomeko yozama ya kusintha kwaposachedwa ndikusanthula matekinoloje a bioprinting.Kupita patsogolo kwa chitukuko cha bioink, kukhazikitsidwa kwa njira zatsopano za bioprinting ndi kukhwima kwa minofu kumafufuzidwanso.Chidwi chapadera chimaperekedwanso pa ntchito ya sayansi ya polima komanso momwe imagwirizanirana ndi 3D bioprinting kuti igonjetse zovuta zina zazikulu pakusindikiza kwa ziwalo, monga kupangitsa biomimetic, angiogenesis ndi 3D anatomy zokhudzana ndi chilengedwe (monga momwe zithunzi zili pansipa zikuwonetsa. ).
Kugwiritsiridwa ntchito kwa njira zowonjezera, monga machitidwe amphamvu a co-culture perfusion, amaonedwa kuti ndi ofunikira kuti atsimikizire kukhwima ndi kusonkhana kwa mapangidwe a minofu ya bioprinted.Ngakhale kuti tsopano ndizotheka kupanga minyewa yamunthu kapena ziwalo zomwe zimatha kukhwima kukhala minyewa yokhazikika komanso yogwira ntchito pang'ono, makampaniwa amatsalirabe m'mbuyo pakusindikiza kwazinthu kapena ziwalo zamunthu chifukwa cha zovuta za matrix amtundu wa extracellular ( ECM) ndi kukhwima kwa minyewa - kusowa kwa media media kuti zithandizire mitundu ingapo yama cell ndipo zimafunikira kukonzanso minofu isanalembedwe.
"Ngakhale 3D bioprinting idakali koyambirira, kudumpha kodabwitsa komwe kwapanga m'zaka zaposachedwa kukuwonetsa zenizeni za ziwalo zogwirira ntchito zomwe zidapangidwa ndi labu.Komabe, kuti tikankhire malire azachipatala, tiyenera kuthana ndi zovuta zaukadaulo zopanga minofu.Ma bioins enieni samakulitsa njira yakukhwima kwa minofu.Izi zidzakhudza kwambiri miyoyo ya odwala, ambiri omwe angadalire tsogolo la 3D bioprinting, "anatero Pulofesa Chua Chee Kai, wolemba wamkulu wa pepalalo.
Zowonjezera za JSNtchito yosindikiza ya 3D yakhala ikukula mosalekeza ndikupita patsogolo, yomwe imafika pamlingo wapamwamba kwambiri mumakampani azachipatala kuti ikwaniritse zosowa za odwala akuluakulu komanso kafukufuku wasayansi.Mitundu yathu yachipatala yosindikizidwa ya 3D ndi zinthu zomalizidwa zimagwiritsidwanso ntchito kwambiri kumayiko akunja.Takulandirani ndikugwiritsa ntchito.
